Hypophosphatasia: Another Possible Cause of Periarticular Swelling?
1. Introduction Hypophosphatasia is a rare genetic metabolic disease caused by mutations of the ALPL gene, which encodes the tissue nonspecific alkaline phosphatase (TNSALP). The most important HPPs biochemical marker are a low activity of the serum ALP, high urine PEA and serum pyridoxal phosphate (PLP) [1]. The HPP onset can occur at any age […]
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