Case Report

1. Introduction Mastocytosis is a disorder that affects children and adults, characterized by an excess of mast cells in the tissues. These excessive cells are most commonly found in the skin and, less frequently, in the lining of the stomach, intestines, bones, and connective tissue.

1. Abstract 1.1. Background: When implanted into a structurally normal heart, leadless pacemakers are more effective and safer than traditional pacemakers. There has been limited experience with leadless pacemakers in cases of severe right heart deformity.

1. Abstract Patients with spontaneous hemothorax or pleural effusion in the absence of trauma or disease- related causes are commonly encountered in poor hospital settings without a cardiothoracic surgeon or underwater seal draining connecting system. In these case reports, a 56-year-old and 25 years patient who presented with dyspnea was diagnosed with spontaneous hemothorax and

1. Abstract We report a case of a 25-year-old woman showing two gestational sacs at obstetric ultrasound at 12 weeks of gestation. Thus, diagnosis of heterotopic pregnancy or a double uterus with a twin pregnancy was suspected.

1. Abstract Fat embolism syndrome (FES) is a rare syndrom which leads to systemic inflammatory cascade affecting multiple organ systems, with high morbidity and mortality rate. It is caused by embolization of fat particles into multiple organs including the brain. No symptom or investigation is completely specific and cerebral multimodal MRI may be the solution.

1. Abstract 1.1. Background: Intrahepatic cholestasis of pregnancy is a reversible cholestasis typically beginning in the second or third trimester and associated with increased rates of stillbirth, preterm birth, fetal asphyxia, and neonatal care unit admission. The etiology of adverse outcomes in gestational cholestasis seems related to maternal bile acids levels, but recommendations for management,

1. Preamble Kimura’s disease is a benign rare inflammatory disorder of unknown aetiology which might mimic neoplastic’s lesion. Epidemiologically this condition, affects young Asian males. Early diagnosis of kimura’s disease may spare the patient from unnecessary invasive diagnostic procedure (surgery-biopsy).

1. Abstract Chediak-Higashi syndrome is a rare autosomal recessive immunodeficiency associated with congenital mutations in the lysosomal trafficking regulator gene (CHS1/LYST).

1. Abstract Histopathology of skin biopsies is invaluable for the diagnosis of skin conditions. However, it is an elaborate and time-consuming procedure whose diagnostic yield depends on the experience of highly trained experts.