A Review of the Decision Process for Risk-Reducing Mastectomy in Adolescents and Young Adults with Li-Fraumeni Syndrome
1. Abstract 1.1. Objective Li-Fraumeni Syndrome is a rare cancer predisposition syndrome caused by autosomal dominant germline mutations in the TP53 gene. LFS is characterized by high lifetime cancer risk, high risk of multiple primary cancers, early cancer onset, and a broad.